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. 2024 Jul 25;14(1):124. doi: 10.1038/s41408-024-01107-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — TCE therapy can lead to T cell exhaustion, characterized by progressive loss of effector function and reduced proliferative capacity. The mechanism underlying this process is thought to be related to persistent antigen stimulation and immunosuppressive tumor microenvironment.