FIG. 2.

Effect of CD8 deficiency on FV-induced splenomegaly. All mice were infected with 1,500 SFFU of FV complex at time zero. Symbols (number of mice in each group): ○, normal B6 (n = 24); ●, CD8-deficient B6 (n = 10); ■, Fv-2^r/s (B10 × A.BY)F₁ CD8-depleted mice (n = 8; the F₁ mice had to be euthanized at 6 weeks postinfection due to severe FV-induced splenomegaly). The difference between the CD8-deficient B6 group and the (B10 × A.BY)F₁ CD8-depleted group was highly significant (P = 0.0004 by the Fisher’s exact test).