TABLE 1.
Effect of CD4+ T-cell deficiency on F-MuLV helper virus replication
| Mouse strain | Fv-2 type | Mean IC titer/spleen ata:
|
|
|---|---|---|---|
| 8 d.p.i. | 30 d.p.i. | ||
| B6 | r/r | 4.1 × 105 | 1.1 × 104 |
| CD4-deficient B6 | r/r | 1.3 × 105 | 1.4 × 107 |
| (B10 × A.BY)F1 | r/s | 4.9 × 106 | ND |
a
The numbers of mice in each group used to determine log10 geometric mean titers were as follows: for B6 mice, n = 5; for B6 CD4 KO mice, n = 5; for (B10 × A.BY)F1 mice, n = 7. ND, not determined; d.p.i., days postinfection. Hematocrits in the B6- and CD4-deficient B6 mice were both in the normal range at 1 week and 4 weeks postinfection. Hematocrits became abnormally high coincident with gross splenomegaly in the CD4-deficient B6 mice (data not shown).