Table 7.
High cholesterol (n = 630) | High LDL cholesterol (n = 629) | Low HDL cholesterol (n = 632) | High triglycerides (n = 631) | |||||
---|---|---|---|---|---|---|---|---|
OR [95%CI] | p-value | OR [95%CI] | p-value | OR [95%CI] | p-value | OR [95%CI] | p-value | |
Age (yrs) | 0.93 [0.88, 0.99] | 0.0137 | 0.91 [0.84, 0.98] | 0.0100 | 1.09 [1.03, 1.15] | 0.0025 | 0.87 [0.82, 0.91] | < 0.0001 |
Sex (ref male) | n.i | n.i | 0.43 [0.29, 0.65] | < 0.0001 | n.i | |||
Glomerular disease (ref CAKUT) | 5.02 [2.65, 9.49] | < 0.0001 | 5.07 [2.47, 10.42] | < 0.0001 | n.i | 1.80 [0.90, 3.59] | 0.0956 | |
Other diagnosis (ref CAKUT) | 1.43 [0.90, 2.26.] | 0.1262 | 1.36 [0.76, 2.45] | 0.3056 | n.i | 0.75 [0.49, 1.14] | 0.1790 | |
eGFR (ml/min/1.73 m2) | 1.02 [1.00, 1.04] | 0.0595 | n.i | 0.97 [0.95, 0.99] | 0.0007 | 0.98 [0.97, 0.99] | 0.0293 | |
Time since CKD2 (years) | n.i | n.i | 0.92 [0.88, 0.96] | 0.0002 | 0.94 [0.91, 0.99] | 0.0076 | ||
Log UACR | 1.38 [1.22 1.57] | < 0.0001 | 1.22 [1.04, 1.43] | 0.0159 | 0.84 [0.74, 0.94] | 0.0032 | n.i | |
Log hsCRP | 0.85[0.74, 0.96] | 0.0109 | n.i | 1.24[1.11, 1.39] | 0.0002 | n.i | ||
BMI-SDS | 1.26 [1.07, 1.48] | 0.0057 | 1.21 [0.99, 1.49] | 0.0577 | n.i | 1.20 [1.05, 1.37] | 0.0090 | |
Serum albumin | n.i | 0.95 [0.91, 0.99] | 0.0274 | 0.93 [0.89, 0.96] | 0.0001 | 0.95 [0.92, 0.99] | 0.0078 | |
Diastolic BP -SDS | n.i | n.i | n.i | 1.25 [1.06, 1.48] | 0.0069 | |||
Lack of physical activity (ref ≥ 1 h per week) | n.i | 1.84 [1.00, 3.36] | 0.0487 | n.i | 1.44 [0.95, 2.18] | 0.0825 | ||
Serum bicarbonate | 1.05 [1.00, 1.11] | 0.0702 | n.i | 0.94 [0.89, 0.99] | 0.0172 | n.i | ||
Serum hemoglobin | n.i | n.i | n.i | n.i | ||||
Non-fasting status (ref fasting) | 1.19 [0.80, 1.78] | 0.3884 | 1.28 [0.79, 2.07] | 0.3223 | 0.94 [0.65, 1.37] | 0.7611 | 0.90 [0.64, 1.28] | 0.5555 |
Multivariable logistic regression for lipids (binary). Variables remaining significant at the 0.1 level after backward selection included, fasting status forced in the model
n.i. not included, OR odds ratio, CI confidence interval, ref reference category, UACR urinary albumin/creatinine ratio