Table 2.

Pharmacokinetic results following twice daily oral dosing of AZ’9567 to rats

AZ’9567	3 mg/kg, BID		10 mg/kg, BID		30 mg/kg, BID
	day 1	day 7	day 1	day 7	day 1	day 7
Free AUC24h (µM*h)	0.69 ± 0.07	0.76 ± 0.11	2.6 ± 1.1	3.9 ± 0.70	12 ± 1.1	9.9 ± 2.2
Free Cmax (µM)	0.04 ± 0.004	0.05 ± 0.01	0.21 ± 0.06	0.27 ± 0.11	0.87 ± 0.19	0.68 ± 0.19
Free Cmin24h (µM)	0.01 ± 0.001	0.01 ± 0.002	0.04 ± 0.02	0.08 ± 0.03	0.14 ± 0.04	0.15 ± 0.05
Fold cover of 1MAT2A biochemical IC50 at mean free Cmin24h	9	9	35	78	143	147

Mean, SD, n = 5

¹as shown in Table 1