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Average methionine plasma concentrations (µmol/L) at baseline and after twice daily oral administration of AZ’9567 for 7 days
| Dose groups | Day 1 | Day 7 |
|---|---|---|
|
Vehicle 3 mg/kg, po, bid |
54 ± 8.4 777±110 |
51 ± 8.9 775 ± 104 |
|
Vehicle 10 mg/kg, po, bid |
54 ± 10 1296 ± 321 |
61 ± 11 1180 ± 279 |
|
Vehicle 30 mg/kg, po, bid |
52 ± 11 1061 ± 170 |
55 ± 10 940 ± 142 |
Mean, SD, n = 30, n.c. not calculated
