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Stability data of control compound in Hepatocytes: Kinetic in vitro clearance and T1/2 for verapamil (1 µM). CLint,inc, = intrinsic in vitro clearance, T1/2 = in vitro half-life
| Species | µM | T1/2 (min) | CLint,inc (µl/min/106 cells) | Limit CLint,inc (µl/min/106 cells) |
|---|---|---|---|---|
| Human | 1 | 22.7 | 30.6 | > 15 |
| Rat | 1 | < 11.4a | > 62a | > 58 |
| Hamster | 1 | < 11.4a | > 62a | NA |
aComplete disappearance in 120 min
