Table 2.
Kinetic in vitro calculations based on the disappearance data in liver S9 and hepatocytes (n = 2)
| Compounds | Test system | Concen. | Half-lives t1/2 (min) | In vitro CLint (μl/min/mg) | ||||
|---|---|---|---|---|---|---|---|---|
| Human | Rat | Hamster | Human | Rat | Hamster | |||
| C8EO4 | Liver S9 | 1 μM | 11.8 | 37.8 | 7.7 | 39.2 | 12.2 | 59.7 |
| 10 μM | 13.8 | 58.1 | 14.5 | 33.6 | 7.95 | 31.8 | ||
| Hepatocyte | 1 μM | 12.9 | 3.2 | 4.3 | 53.7 | 220 | 160 | |
| 10 μM | 12 | 3.6 | 6.5 | 57.7 | 191 | 107 | ||
| C10EO5 | Liver S9 | 1 μM | 2.0 | 8.3 | 8.1 | 234 | 55.7 | 57.3 |
| 10 μM | 2.7 | 12 | 12 | 170 | 38 | 40 | ||
| Hepatocyte | 1 μM | 4.0 | 2.9 | 4.5 | 172 | 236 | 153 | |
| 10 μM | 4.9 | 1.9 | 10.6 | 140 | 357 | 65.4 | ||
| C12EO4 | Liver S9 | 1 μM | NA | 26 | NA | NA | 17.5 | NA |
| 10 μM | 9.0 | 11 | 26 | 51.2 | 40.7 | 17.9 | ||
| Hepatocyte | 1 μM | NA | NA | 789 | NA | NA | 0.88 | |
| 10 μM | 15 | 8.9 | 17 | 47.4 | 78.0 | 39.7 | ||
| C16EO8 | Liver S9 | 1 μM | 139 | 16 | 118 | 3.33 | 29.6 | 3.92 |
| 10 μM | NA | NA | NA | NA | NA | NA | ||
| Hepatocyte | 1 μM | 39 | 6.6 | 27 | 17.6 | 104 | 25.7 | |
| 10 μM | 85 | 9.2 | 30 | 8.13 | 75 | 23.4 | ||
| C18EO3 | Liver S9 | 1 μM | 29 | 32 | 29 | 15.9 | 14.6 | 16.2 |
| 10 μM | NA | NA | NA | NA | NA | NA | ||
| Hepatocyte | 1 μM | NA | NA | NA | NA | NA | NA | |
| 10 μM | NA | NA | NA | NA | NA | NA | ||
NA not available