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. 2024 Jul 12;15:1402038. doi: 10.3389/fimmu.2024.1402038

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Copyright © 2024 Tahiat, Belbouab, Yagoubi, Hakem, Fernini, Keddari, Belhadj, Touri, Aggoune, Stoddard, Niemela, Zerifi, Melzi, Aboura, Saad-Djaballah, Ferhani, Ketfi, Messaoudi, Bencharif Madani, Benhacine, Dehimi, Okka, Amroune, Fellahi, Bendahmane, Khoulani, Oukil, Soufane, Bourelaf, Boubidi, Boukhenfouf, Amine Ifri, Khelafi, Boudiaf, Khelifi Touhami, Meçabih, Boucelma, Zelaci, Gacem, Ladj, Mekki, Bensaadi, Benhalima, Zeroual, Bioud, Benameur, Bouhdjila, Bouzerar, Ibsaine, Maouche, Kedji, Smati, Boukari, Lambert, Rosenzweig, Notarangelo and Djenouhat

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B-cell subpopulation analysis in two CVID patients and one healthy control. CVID patient (A) has reduced memory B-cell subsets including switched memory (CD27+sIgD-) and non-switched memory (CD27+sIgD+) B cells (middle panel). CVID patient (B) shows an expansion of CD21^lo B cells (right panel). CVID, common variable immunodeficiency; sm, switched memory; nsm, non-switched memory.