Table 4. Association of Neonatal Morbidities With Treatment-Warranted ROP in the Norwegian Neonatal Network.
| Variablea | Univariable analysis, OR (95% CI) | P value | Multivariable analysis, aOR (95% CI) | P value |
|---|---|---|---|---|
| Neonatal sepsis | 2.16 (1.48-3.14) | <.001 | 0.97 (0.64-1.47) | .88 |
| Sepsis episodes, No.b | ||||
| 1 | 1.61 (1.04-2.50) | .03 | 0.77 (0.47-1.23) | .29 |
| 2 | 5.30 (2.72-10.34) | <.001 | 1.96 (0.94-4.10) | .07 |
| 3 | 6.29 (1.60-24.73) | .008 | 1.89 (0.40-8.83) | .42 |
| NEC requiring surgery | 7.30 (4.12-12.95) | <.001 | 3.37 (1.78-6.37) | <.001 |
| SGA | 1.47 (1.01-2.15) | .05 | 1.53 (1.01-2.32) | .04 |
| GA, wkc | 0.54 (0.48-0.60) | <.001 | 0.63 (0.54-0.72) | <.001 |
| Severe BPD | 3.84 (2.69-5.46) | <.001 | 1.80 (1.21-2.67) | .004 |
| Apgar score at 5 min <7 | 0.58 (0.41-0.82) | .002 | 1.02 (0.71-1.52) | .83 |
Abbreviations: aOR, adjusted odds ratio; BPD, bronchopulmonary dysplasia; GA, gestational age; NEC, necrotizing enterocolitis; OR, odds ratio; ROP, retinopathy of prematurity; SGA, small for gestational age.
a
Variables not associated with treatment-warranted ROP in univariable analysis were female sex, intraventricular hemorrhage grade 3 to 4, and cystic periventricular leukomalacia.
b
The reference group was infants with 0 sepsis episodes.
c
Outcomes were per 1-week increase in GA.