Polymeric micelles for targeting integrin, nucleolin and transferrin receptors.

PMs	Drugs	Targeting ligand	Grafting mode	Target organ	Receptor	Key consequences	Ref.
PEG-β-CD-PCL	DOX	Ang-2 and cRGD peptide	Click reaction	Brain	LRP-1	Potent in vivo therapeutic effect owing to superior brain targeting	42
					αvβ3 integrin
mPEG-b-pHPMAmLacn	DTX	cRGD peptide	BCN conjugation		αvβ3 integrin	Enhanced uptake for the lower density cRGD decorated micelles	43
MSNPs-MM	PTX	RGD peptide	EDC conjugation reaction	—	αvβ3 integrin	Superior in vitro cellular uptake and antitumor effect	44
	DOX
PEG-PCL	PTX	F3 peptide	Thiole–maleimide coupling reaction	Breast	Nucleolin	Prominent in vivo performance due to better accumulation and pharmacokinetics	45
D/PLA-PEI	CPT sur-shRNA	AS1411 aptamer	EDC conjugation reaction	Colon	Nucleolin	Eminent in vivo synergistic action owing to preferable tumor homing	46
β-CD/(PCL-PAEMA)21	CPT	AS1411 aptamer	Sulfo-SMCC crosslinker	Breast	Nucleolin	Powerful in vivo performance owing to stronger selectivity	47
PEG3400-PE	TRQ	Transferrin		—	Transferrin	Enhanced in vitro antitumor activity via TF-mediated uptake	48
	PTX
VPM	CUR	Transferrin	Post insertion method	—	Transferrin	Powerful in vitro antitumor activity for targeted PMs	49
PEG-PLA	PTX	TF-T12	EDC conjugation reaction	Brain	Transferrin	Improved in vivo anti-tumor effect due to higher tumor accumulation	50