Table 2.

Studies on the antioxidant effect of metallothionein.

Metallothionein Source	Target of Action	Effect	Reference
GST-AmMT2 expressed in E. coli	E. coli	Enhance tolerance of E. coli to H2O2	[46]
Self-expressed metallothionein in mice	Mice	Relief of oxidative stress and damage to the lungs	[45]
Self-expressed metallothionein in mice	Mice	Inhibited PPE-induced ROS production in the lungs	[47]
rh-MT-III	Caenorhabditis elegans	Reduced levels of malondialdehyde and reactive oxygen species	[48]
Metallothionein 2A gene from date palm expressed by yeast and Arabidopsis thaliana	yeast and Arabidopsis thaliana	Improved oxidative stress tolerance	[42]
MT3 expressed by C2C12 cells	C2C12 cells	Reduced oxidative stress during osteoblast differentiation	[49]
MT2A gene expressed by HT1376 cells	HT1376 cells	Inhibited H2O2-induced ROS production	[50]
MT3 expressed by 3T3-L1 cells	3T3-L1 cells	Reduced levels of ROS at the adipose differentiation stage	[51]
Metallothionein expressed in mouse cardiomyocytes	Mouse cardiomyocytes	Reduction of superoxide anion radical production and glutathione levels	[52]
GmMT-II expressed by transgenic Arabidopsis	Transgenic Arabidopsis	Enhanced activities of SOD, CAT, and POD	[53]
LcMT3 expressed by transgenic Arabidopsis thaliana	Transgenic Arabidopsis	Reduced accumulation of malondialdehyde and reactive oxygen species and increased activities of SOD, POD, and CAT	[54]