Skip to main content
. 2024 Jun 27;13(7):782. doi: 10.3390/antiox13070782

Table 5.

Comprehensive summary of experimental designs employed in the articles reviewed in the multiorgan impact section.

Article Experimental Target System Dosage Exposure Time Administration Route Ameliorative Effects of Resveratrol
Cd RV Cd RV Cd RV
Mei et al. (2021) [150] § ERK1/2 and JNK pathways 10 μM 10 μM 48 h 48 h NA NA ↑ cell viability; differentiation; ALP, RUNX2, COL1, and BMP-2 activity/expression; p-ERK1/2 and p-JNK
↓ apoptosis and necrosis; phosphorylation of ERK1/2 and JNK
Sasikumar et al. (2023) [153] § Oxidative stress, MMP, Nrf2, and downstream genes 3 μM 20 μM 24 h 24 h NA NA ↑ cell viability; Nrf2 and downstream genes (HO-1, NQO1, SOD, CAT)
↓ Cd-induced structural abnormalities; expression of hypertrophic markers (ANP, BNP, βMHC)
Qian et al. (2021) [159] § EMT (in colorectal cancer) 1–10 μM 10–200 μM 24 h 24 h NA NA ↑ E-cadherin
↓ invasive ability of CRC cells; ZEB1, vimentin, and N-cadherin levels

§: in vitro; NA: not applicable; h: hours; MMP: mitochondrial membrane potential; EMT: epithelial–mesenchymal transition; ↑: increase; ↓: decrease/inhibition.