Table 5.
Article | Experimental Target System | Dosage | Exposure Time | Administration Route | Ameliorative Effects of Resveratrol | |||
---|---|---|---|---|---|---|---|---|
Cd | RV | Cd | RV | Cd | RV | |||
Mei et al. (2021) [150] § | ERK1/2 and JNK pathways | 10 μM | 10 μM | 48 h | 48 h | NA | NA | ↑ cell viability; differentiation; ALP, RUNX2, COL1, and BMP-2 activity/expression; p-ERK1/2 and p-JNK ↓ apoptosis and necrosis; phosphorylation of ERK1/2 and JNK |
Sasikumar et al. (2023) [153] § | Oxidative stress, MMP, Nrf2, and downstream genes | 3 μM | 20 μM | 24 h | 24 h | NA | NA | ↑ cell viability; Nrf2 and downstream genes (HO-1, NQO1, SOD, CAT) ↓ Cd-induced structural abnormalities; expression of hypertrophic markers (ANP, BNP, βMHC) |
Qian et al. (2021) [159] § | EMT (in colorectal cancer) | 1–10 μM | 10–200 μM | 24 h | 24 h | NA | NA | ↑ E-cadherin ↓ invasive ability of CRC cells; ZEB1, vimentin, and N-cadherin levels |
§: in vitro; NA: not applicable; h: hours; MMP: mitochondrial membrane potential; EMT: epithelial–mesenchymal transition; ↑: increase; ↓: decrease/inhibition.