Table 3.

Cortical thickness (mm) profiles in healthy controls (HC), C9orf72-negative patients with ALS (C9-ALS) and C9orf72-positive patients with ALS (C9+ALS). Estimated marginal means (EMM) and standard errors (SE) were adjusted for age, sex and handedness. Significant intergroup differences at p < 0.05 after Bonferroni correction for multiple comparisons are highlighted in bold print.

Limbic Structure	Study Group	Descriptive Values		Statistics
		EMM	Standard Error	Univariate F, p-Value	C9-ALS vs. HC	C9+ALS vs. HC	C9- vs. C9+
ACC-caudal L	C9-ALS	2.589	0.017	F = 2.491; p = 0.084	0.915	0.084	0.263
	C9+ALS	2.498	0.050
	HC	2.619	0.022
ACC-rostral L	C9-ALS	2.657	0.015	F = 10.563; p < 0.001	0.010	<0.001	0.016
	C9+ALS	2.530	0.043
	HC	2.730	0.019
Entorhinal cortex L	C9-ALS	3.255	0.028	F = 6.227; p = 0.002	0.006	0.035	1.000
	C9+ALS	3.178	0.079
	HC	3.398	0.035
Parahippocampal gyrus L	C9-ALS	2.749	0.021	F = 2.152; p = 0.118	0.121	1.000	1.000
	C9+ALS	2.763	0.061
	HC	2.822	0.027
PCC L	C9-ALS	2.447	0.012	F = 6.718; p = 0.001	0.376	<0.001	0.011
	C9+ALS	2.343	0.034
	HC	2.477	0.015
ACC-caudal R	C9-ALS	2.436	0.016	F = 7.523; p < 0.001	<0.001	0.076	1.000
	C9+ALS	2.422	0.016
	HC	2.534	0.021
ACC-rostral R	C9-ALS	2.777	0.015	F = 2.804; p = 0.062	0.073	0.500	1.000
	C9+ALS	2.768	0.015
	HC	2.833	0.019
Entorhinal cortex R	C9-ALS	3.319	0.028	F = 3.881; p = 0.022	0.022	0.380	1.000
	C9+ALS	3.309	0.079
	HC	3.442	0.036
Parahippocampal gyrus R	C9-ALS	2.734	0.017	F = 0.963; p = 0.383	1.000	0.569	1.000
	C9+ALS	2.687	0.049
	HC	2.758	0.022
PCC R	C9-ALS	2.418	0.013	F = 8.700; p < 0.001	0.217	<0.001	0.003
	C9+ALS	2.291	0.037
	HC	2.456	0.016