Table 2.
Odds ratio (ORs) and 95% confidence interval (CIs) for treatment tolerance and treatment efficacy by pre-diagnosis recreational physical activity levels (n=180).
| Pre-diagnosis recreational physical activity level, MET-hrs/wk | ||||
|---|---|---|---|---|
| <3.0 | 3.0 – <13.2 | ≥13.2 | P trend | |
| * Chemotherapy completion (n=153) | ||||
| No. population | 54 | 48 | 51 | |
| No. cases (%) | 42 (77.8) | 37 (77.1) | 36 (70.6) | |
| OR (95% CI) a | 1.00 (reference) | 1.02 (0.39, 2.66) | 0.82 (0.33, 2.04) | P trend = 0.64 |
| OR (95% CI) b | 1.00 (reference) | 0.86 (0.27, 2.75) | 0.87 (0.30, 2.56) | P trend = 0.84 |
| * Dose delay (n=140) | ||||
| No. population | 52 | 39 | 49 | |
| No. cases (%) | 15 (28.8) | 12 (30.8) | 19 (38.8) | |
| OR (95% CI) a | 1.00 (reference) | 1.06 (0.42, 2.69) | 1.32 (0.56, 3.10) | P trend = 0.51 |
| OR (95% CI) b | 1.00 (reference) | 1.17 (0.39, 3.54) | 1.45 (0.54, 3.92) | P trend = 0.46 |
| pCR (ypT0 ypN0) (n=180) | ||||
| No. population | 60 | 60 | 60 | |
| No. cases (%) | 14 (23.3) | 11 (18.3) | 20 (33.3) | |
| OR (95% CI) a | 1.00 (reference) | 0.74 (0.30, 1.81) | 1.52 (0.66, 3.50) | P trend = 0.22 |
| OR (95% CI) b | 1.00 (reference) | 0.67 (0.22, 2.01) | 1.28 (0.49, 3.34) | P trend = 0.42 |
MET=metabolic equivalent task, OR=odds ratio, CI=confidence interval, pCR=pathological complete response
*
Missing: chemotherapy completion n=27 (15.0%), dose delay n=40 (22.2%)
a
Adjusted for age at diagnosis and BMI.
b
Additionally adjusted for race/ethnicity, alcohol intake, menopause status, hormone replacement therapy use, tumor stage, tumor receptor status, and receiving neoadjuvant biological therapy.