Table 4.
Spectrum of Activity.
| Ambler Class | CEF-TANI | CEF-EM | CEF-ZIDE | SUL-DUR | Sulopenem | AZT-AVI |
|---|---|---|---|---|---|---|
| Class A: | ||||||
| CTX-M | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| KPC | ✓ | ✓ | ✓ | ✓ | — | ✓ |
| Class B: | ||||||
| NDM | ✓ | — | ✓ | — | — | ✓ |
| VIM | ✓ | — | ✓ | — | — | ✓ |
| IMP | — | — | ✓ | — | — | ✓ |
| Class C: | ||||||
| AmpC | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Class D: | ||||||
| OXA-48 | ✓ | ✓ | ✓ | ✓ | — | ✓ |
| Pathogens of Interest | ||||||
| CRE | ✓ | ✓ | ✓ | — | — | ✓ |
|
DTR
Pseudomonas |
✓ | ✓ | ✓ | — | — | ✓ |
| CRAB | — | — | — | ✓ | — | — |
| Stenotrophomonas | — | — | — | — | — | ✓ |
Abbreviations: AZT-AVI (Aztreonam-avibactam); CEF-EM (cefepime-enmetazobactam); CEF-TANI (cefepime–taniborbactam); CEF-ZIDE (cefepime-zidebactam); CRAB (carbapenem-resistant Acinetobacter baumannii); CRE (carbapenem-resistant Enterobacterales); CTX-M (cefotaxime-hydrolyzing beta-lactamase isolated in Munich), DTR (difficult-to-treat resistance); IMP (active on imipenem) (imipenem-hydrolyzing beta-lactamase); KPC (Klebsiella pneumoniae carbapenemase); NDM (New Delhi metallo-beta-lactamase); OXA (oxacillinase), SUL-DUR (sulbactam-durlobactam); VIM (Verona integron-encoded metal-beta-lactamase).