Table 3.
Nucleosome levels and sepsis severity.
| Author [Ref.] | Sample Collection Time | Nucleosome Levels Predict Sepsis Severity | Severity Score | ||
|---|---|---|---|---|---|
| SOFA | APACHE II | SAPS II | |||
| Haem Rahimi et al. [66] | Daily (D1–D8) | Yes | r = 0.4 (p < 0.0001) |
NR | r = 0.2 (p = 0.008) |
| Rai et al. [68] | Single (within 24 h of diagnosis) | No | 0.08 (p = 0.46) |
0.10 (p = 0.34) |
NR |
| Morimont et al. [69] | Single (admission) | Yes | 0.61 | 0.47 | NR |
| Duplessis et al. [73] | Daily (T0 and T24) | Yes (a small correlation) | NR | 0.24 | NR |
| Kaufman et al. [74] | Within 24 h of admission and on day 4 | No | R2 = 0.195 (p = 0.0362) |
NR | NR |
| Miki et al. [77] | Days 0, 1, 3, 7 | No | NR | NR | NR |
| Zeerleder et al. [80] | Days 0–8 | Yes | R = 0.44 (p = 0.008) |
NR | NR |
| Chen et al. [81] | Admission, days 1, 3, 5, 7 | Yes | Admission r = 0.21 (p = 0.03) | Admission r = 0.24 (p = 0.01) | NR |
| Zeerleder et al. [83] | Admission | Yes | NR | NR | NR |
SOFA: sequential organ failure assessment, and NR: not reported.