Table 4.

Nucleosome levels and sepsis prognosis.

Author [Ref.]	Survivors	Non-Survivors	p Value [Survivors vs. Non-Survivors]	Prediction of Mortality
Haem Rahimi et al. [66]	1333.14 [385.14–3637.92] ng/mL	1919 [880.75–12,098.9] ng/mL	0.006	Cut-off 4639 ng/mL AUC 0.63
Eichhorn et al. [67]	0.09 [0.05; 0.11] AU	0.11 [0.05; 0.2] AU	NS	NR
Rai et al. [68]	185.0 [68.0–1721.0] pg/µL	345.0 [65.0–1584.2] pg/µL	0.004	Cut-off 215.0 [pg/μL] AUC: 0.68 [95% CI 0.56–0.80] Odds ratio 3.42 [1.35–8.68]
Morimont et al. [69]	785.2 [173.4–3076.1] ng/mL	901.6 [402.7–16,032.5] ng/mL	0.0664	NR
Duplessis et al. [73]	3.2 ± 9.1 µg/mL	5.0 ± 4.9 µg/mL	0.007	T0: AUC: 0.75 T24: AUC: 0.67
Kaufman et al. [74]	NR	NR	NR	Yes, Wald = 5.31
Raffray et al. [76]	9.2 AU	71.8 AU	p < 0.0001	NR [available from figure]
Miki et al. [77]	NR	NR	NS	Day 7 AUC: 0.57
Huson et al. [78]	60 [25–135] AU/mL	333 [298–456] AU/mL	0.0002	NR
de Jong et al. [79]	33.6 ± 4 AU/mL	192.3 ± 5 AU/mL	0.001	NR
Zeerleder et al. [80]	583 (47–2329) AU/mL	2244 [610–8638] AU/mL	0.0061	NR
Chen et al. [81]	1.97 AU	2.58 AU	0.06	NR
Zeerleder et al. [83]	276 [35–1947] AU/mL	628 [35–1979] AU/mL	0.333	NR

AUC: area under the receiver operating characteristic curve; AU: artificial unit; NR: not reported; and NS: not significant.