Table 1.
Baseline demographic and biochemical parameters in patients treated with TKIs, analyzing differences in relation to sex using the chi-square test or the Mann–Whitney test as appropriate.
| Whole Cohort (n = 35) (%) |
M (n = 29) (%) |
F (n = 6) (%) |
p | |
|---|---|---|---|---|
| Age at diagnosis (M ± SD) | 65.0 ± 9.6 | 63.5 ± 9.9 | 72.3 ± 3.4 | 0.04 |
| Age at TKI start (M ± SD) | 66.4 ± 9.9 | 64.8 ± 10.1 | 73.8 ± 4.3 | 0.04 |
| Deaths | 31 (88.6) | 27 (93.1) | 4 (66.7) | 0.06 |
| Etiology | 0.46 | |||
| HCV | 17 (48.6) | 13 (44.8) | 4 (66.7) | |
| HBV | 5 (14.3) | 5 (17.2) | 0 | |
| Dysmetabolic | 13 (37.1) | 11 (37.9) | 2 (33.3) | |
| Child–Pugh class (A or B) | 30, 5 | 27, 2 | 3, 3 | 0.06 |
| HCC grade (1, 2, or 3) | 10, 16, 9 | 8, 13, 8 | 2, 3, 1 | 0.98 |
| Extra-hepatic localization | 16 (55.2) | 16 (55.2) | 0 | 0.01 |
| Site of extra-hepatic localization | ||||
| Lung | 8 | 8 | 0 | |
| Bone | 4 | 4 | 0 | |
| Lymph nodes | 4 | 4 | 0 | |
| Peritoneum | 4 | 4 | 0 | |
| Time HCC diagnosis–death (months) (M ± SD) | 37.7 ± 28.6, 32 | 27.5 ± 24.0 | 47.5 ± 19.9 | 0.44 |
| Time TKIs–death (months) (M ± SD) |
16.8 ± 11.0, 16 | 14.6 ± 8.9 | 27.8 ± 14.3 | 0.44 |
| TKI response (CR, SD, or PD) | 2, 9, 24 | 0, 7, 22 | 2, 2, 2 | 0.04 |
| Overall time on TKIs | 11.1 ± 10.9 | 9.1 ± 8.4 | 21.1 ± 16.5 | 0.07 |
| Bilirubin (mg/dL) (M ± SD) | 1.4 ± 1.6, 0.93 | 1.9 ± 2.5 | 1.2 ± 0.8 | 0.96 |
| Albumin (g/dL) (M ± SD) | 3.9 ± 0.46, 4.00 | 3.9 ± 0.5 | 4.1 ± 0.07 | 0.40 |
| INR (M ± SD, median) | 1.13 ± 0.18, 1.09 | 1.1 ± 0.1 | 1.1 ± 0.1 | 0.87 |
| Creatinine (mg/dL) (M ± SD) | 1.02 ± 0.33, 0.91 | 1.0 ± 0.3 | 1.0 ± 0.2 | 0.68 |
| Platelets (109/L) (M ± SD) | 148 ± 101 | 148 ± 124 | 118 ± 18 | 0.85 |
| AFP (ng/mL) (M ± SD) | 6634 ± 17,984 | 4148 ± 13,755 | 30,252 ± 42,777 | 0.77 |