Table 3.

Univariate and multivariate Cox regression analysis for survival.

	Univariate Analysis		Multivariate Analysis
Variables	HR (95% CI)	p	HR (95% CI)	p
Age at diagnosis	0.978 (0.941–1.016)	0.260
Sex	0.425 (0.146–1.233)	0.115
Etiology	0.869 (0.586–1.287)	0.483
Varices	1.142 (0.455–2.868)	0.777
PVT	1.346 (0.568–3.186)	0.500
HCC grade	1.141 (0.736–1.769)	0.556
Extra-hepatic localization *	1.982 (0.928–4.237)	0.077
Time on TKIs	0.950 (0.911–0.990)	0.015	0.944 (0.893–0.998)	0.043
Tumoral Ang2	1.334 (0.025–71.640)	0.887
Endothelial Ang2	0.253 (0.002–35.210)	0.586
LEC podoplanin *	0.027 (0.001–0.876)	0.042	0.009 (0.000–0.842)	0.042
Tumoral CLEC-2	0.641 (0.009–47.284)	0.840
Bilirubin	0.835 (0.585–1.191)	0.320
INR	0.637 (0.041–9.826)	0.747
Albumin	0.762 (0.290–2.007)	0.583
Creatinine	0.970 (0.257–3.657)	0.965
Platelets	1.000 (1.000–1.000)	0.189
AFP	1.000 (1.000–1.000)	0.408

* Collinear with LEC podoplanin.