Table 1.

Vedolizumab pharmacokinetic parameters after a single IV dose [29,30].

	Vedolizumab Dose [mg/kg]
	Healthy Volunteers		UC Patients
Parameter	2.0 ($\mathit{n}=7$)	10.0 ($\mathit{n}=7$)	2.0 ($\mathit{n}=10$)	10.0 ($\mathit{n}=11$)
$C_{max}$ [μg/mL]	58.4	243	60.4	291.9
AUC [μg·day/mL]	955	4840	848	4373
$t_{1/2} \left[\mathrm{day}\right]$	14.1	14.8	15.1	20.6
$CL$ [L/day]	0.164	0.139	-	-
$V_z$ [L]	3.28	2.73	-	-

$C_{max}$, maximum observed serum concentration; $AUC$, area under the drug concentration–time curve (evaluated until the time of the last quantifiable concentration for healthy volunteers and between days 0 and 14 and days 85 and 99 for UC patients); $t_{1/2}$, terminal estimation half-life; $CL$, total clearance; $V_z$, volume of distribution during the terminal phase.