Table 3.

Parameters adopted in the three-compartmental model.

Parameter	Notation	Value	Reference
Blood flow rate [L/g]	$Q_b$	0.12	[41]
Vedolizumab kinetic constant [g−1]	$K$	0.0368	[This Work]
Central blood compartment volume [L]	$V_1$	3.12	[41]
Peripheral blood compartment volume [L]	$V_2$	1.65	[41]
MAdCAM-1 initial concentration [mg/L]	$M_0$	2.23 × 10−2	[53]
$\mathrm{Maximum} \mathrm{Vedolizumab} \mathrm{effect} [\cdot ]$	$E_{max}$	0.956	[41]
$\mathrm{Hill} \mathrm{coefficient} [\cdot ]$	$\gamma$	0.3512	[This Work]
Vedolizumab concentration at half-maximum effect [mg/L]	$E_{50}$	0.093	[41]