Figure 6.

Prolonged sleep deprivation alters the circadian rhythm of multiple metabolic pathways. Heatmaps and fitted curve plots depicting the regulation of protein catabolic process genes (from III): (A,B) the response to insulin (from III); (C,D) the generation of precursor metabolites and energy (E,F) and fatty acid metabolic process genes (from IV); (G,H) heat map of genes enriched in the sleep-deprived (SD) and control (Control) groups. Each sample is represented by a column, and a line represents each gene. Each line in the fitted curve represents a gene; the expression of each gene is standardized to a range of −1 to 1, and the horizontal axis represents the ZT time. The data for ZT24 in the figure are the data for the replicated ZT0.