Systemic causes	Main systemic features
Genetic defects
Down's syndrome	Learning disability, short stature
Papillon-Lefèvre syndrome	Palmar-plantar hyperkeratosis
Juvenile periodontitis and related disorders	Sometimes neutrophil defects
Ehlers-Danlos syndrome type VIII	Hypermobility
Chédiak-Higashi syndrome	Recurrent infections
Eosinophilic granuloma	Bone lesions
Immune defects
Neutropenia	Recurrent infections
Neutrophil defects	Recurrent infections
Monocyte defects	Recurrent infections
Interleukin 1 abnormalities	Recurrent infections
HIV infection and AIDS	Recurrent infections
Enzyme defects
Acatalasia (absent catalase)	Recurrent infections
Hypophosphatasia (low alkaline phosphatase)	Recurrent infections