Table 2.
Histopathological results of cardiac tissue analyses.
| Group | Fibrosis | ||||
|---|---|---|---|---|---|
| Type | Number of Cases with Increased Fibrosis | Overall Grade | Location | Distribution | |
| SHAM | Absent | 0/8 | None | ||
| PNx week 4 | Interstitial | 3/3 | Mild | Sub-endocardium | Focal |
| PNx week 8 | Interstitial | 5/5 | Mild | Sub-endocardium | Multifocal |
| PNx + vehicle | Interstitial | 6/7 | Mild | Sub-endocardium | Focal |
| PNx + EVs Dose 1 | Interstitial | 1/10 | Mild | Sub-endocardium | Focal |
| PNx + EVs Dose 2 | Interstitial | 1/6 | Mild | Sub-endocardium | Focal |
| PNx + EVs Dose 3 | Interstitial | 1/6 | Moderate | Sub-endocardium | Focal |