Table 2.
Comparison of driver alterations between liquid biopsies to matched tissue results.
| Genomic Alteration | Total Cases with Matched Tissue | Mutations Found in Tissue and Plasma | Mutations Found in Tissue Only | |
|---|---|---|---|---|
| SNVs, INDELs, CNVs (DNA) | n | n (%) | n (%) | |
| BRAF | 1 | 1 | - | |
| EGFR | 31 | 23 | 8 | |
| ERBB2 | 3 | 3 | - | |
| ERBB4 | 1 | - | 1 | |
| KRAS AMPLIFICATION | 1 | 1 | - | |
| KRAS POINT MUTATION | 13 | 7 | 6 | |
| MET AMPLIFICATION | 1 | - | 1 | |
| MET SPLICING MUTATION | 3 | 3 | - | |
| PIK3CA | 3 | 3 | - | |
| Total DNA alterations | 57 | 41 (72%) | 16 (28%) | |
| FUSIONS (RNA) | n | n (%) | n (%) | |
| ALK | 4 | 2 | 2 | |
| FGFR1 | 1 | 1 | - | |
| MET FUSION | 3 | 1 | 2 | |
| NTRK | 1 | - | 1 | |
| RET | 1 | - | 1 | |
| ROS1 | 1 | 1 | - | |
| Total RNA alterations | 11 | 5 (46%) | 6 (55%) | |
| NO ALTERATIONS IDENTIFIED | 7 | 7 (100%) | ||
| Total alterations | 75 | 53 (71%) | 22 (29%) | |
SNV—single nucleotide variants; INDELs—insertion/deletion mutations; CNV—copy number variants.