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. 2024 Jul 11;13(14):1184. doi: 10.3390/cells13141184

Figure 2.

Figure 2

FSO pretreatment prevented TMT-induced hippocampal damage 21 days post intoxication. (a) Representative thionin-stained coronal sections obtained from control (Ctrl), trimethyltin (TMT), and flaxseed oil (FSO)-treated TMT-intoxicated (FSO+TMT) animals. Arrowheads indicate injured neuronal cell layers in the pCA3 subfield of the hippocampus, while the laminar organization of pCA3 was regular in the FSO-treated TMT sections. Scale bar = 500 μm. (b) Relative protein abundances and representative immunoblots of Bax, Bcl-2, and Caspase3 (Casp3) in Ctrl, FSO, TMT, and FSO+TMT animals. Bars represent mean protein abundance relative to β-actin ± SD, from n = 5 hippocampi per group. Significance shown inside the graphs: * p < 0.05 or less relative to Ctrl; # p < 0.05 or less relative to TMT. pCA3, proximal CA3 subfield of the hippocampus; DG, dentate gyrus; 21 dpi, 21 days post TMT intoxication.