Figure 7.

Schematic representation of alcohol-induced astrocytic amyloid generation leading to oxidative stress and neuroinflammation, mediated by lncRNA BACE1-AS. Created with Biorendor.com (https://app.biorender.com/user/signin, accessed on 4 July 2024). Abbreviations: APP, amyloid precursor protein; Aβ, amyloid beta; BACE1, β-site-cleaving enzyme; long noncoding RNA (lncRNA) BACE1-AS, BACE1-antisense transcript; ADH, alcohol dehydrogenase; ALDH2, aldehyde dehydrogenase 2; CYP2E1, cytochrome P450 2E1; ROS, reactive oxygen species; NAD⁺, nicotinamide adenine dinucleotide; NADP⁺, nicotinamide adenine dinucleotide phosphate; H₂O₂, hydrogen peroxide.