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. 2024 Jul 8;14(7):808. doi: 10.3390/biom14070808

Figure 4.

Figure 4

Lgals3bp KO C57BL6/J mice infected with WNV-NS5-E218A suffer increased severity of infection without a difference in survival or CNS viral titers. (A) Schematic demonstrating targeting sites of gRNA in exon 2 (arrow) of C57BL6/J mouse Lgals3bp gene used to generate Lgals3bp−/− animals. Weight loss (B) and survival (C) of WNV-infected Lgals3bp−/−, Lgals3bp+/− and WT animals. (D) CNS viral titers of WNV measured in the cortex and cerebellum via plaque assay. * denotes a p-value less than 0.05.