Table 1.

Transcriptional changes of cluster-defining genes of WNV-activated microglia during aging.

Gene	Fold Change (Old/Young) [28]	p Value [28]	Fold Change (WNV/Mock) [12]	p Value [12]
Apoe	3.56	5.8 × 10−18	4.46	2.93 × 10−38
H2-D1	3.29	1.8 × 10−20	8.29	1.46 × 10−170
Fth1	2.74	3.0 × 10−18	1.41	8.71 × 10−11
Lgals3bp	2.24	5.7 × 10−23	5.65	2.20 × 10−121
H2-Q6	2.23	1.1 × 10−10	2.29	0.00
Oasl2	1.89	1.9 × 10−5	15.52	1.08 × 10−85
Ifi204	1.79	1.0 × 10−4	12.84	4.66 × 10−76
Fcgr4	1.75	2.6 × 10−4	7.22	7.98 × 10−53
C1qa	1.75	4.5 × 10−6	−1.27	1.73 × 10−46
Ifitm3	1.72	4.0 × 10−13	10.02	8.85 × 10−232
ltm2b	1.63	6.4 × 10−5	−1.06	0.01
Ftl1	1.51	0.022	1.28	0.759
Tyrobp	1.50	0.002	−1.40	3.63 × 10−44
Ctsb	1.47	1.8 × 10−4	1.15	1.27 × 10−9
Rps29	1.39	0.212	1.68	1.92 × 10−17
C1qb	1.37	0.026	1.01	0.327
Fau	1.36	0.213	2.30	4.64 × 10−48
Fcer1g	1.35	0.010	−1.14	1.36 × 10−37
H2-Ab1	1.34	0.002	9.06	2.17 × 10−166
Ctss	1.32	0.002	1.23	2.40 × 10−8
Ly6e	1.26	0.005	1.97	3.54 × 10−24
H2-Eb1	1.25	0.014	7.52	3.96 × 10−176
H2-Aa	1.15	0.326	8.92	5.82 × 10−180
CD74	1.14	0.404	11.45	3.51 × 10−213
Cxcl9	1.12	0.722	261.85	2.15 × 10−27
Psap	0.93	0.846	−1.03	6.49 × 10−23
Selplg	1.11	0.652	−2.50	2.40 × 10−25
Fscn1	1.04	0.917	-5.40	8.67 × 10−207
Hexb	1.00	0.986	−2.41	3.23 × 10−606
Cst3	0.99	0.964	−3.03	1.52 × 10−127
Hpgd	0.88	0.326	−2.57	1.65 × 10−80
Pmp22	0.86	0.149	−5.41	2.97 × 10−166
Selenop	0.85	0.242	−2.60	5.19 × 10−87
Csf1r	0.84	0.241	−2.58	5.73 × 10−88
Sparc	0.82	0.237	−2.96	5.21 × 10−11
Rnase4	0.80	0.007	−2.78	2.80 × 10−85
Golm1	0.74	0.091	−3.32	1.35 × 10−98
Siglech	0.73	0.002	−2.85	3.28 × 10−112
Cx3cr1	0.73	0.157	−3.07	3.42 × 10−99