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. 2024 Jul 15;16(14):2541. doi: 10.3390/cancers16142541

Table 3.

Comparison of non-fertility sparing management in early stage cervical cancer in different guidelines. Cone: conization; SH: simple hysterectomy; SLN: sentinel lymph-node; RT: radical hysterectomy; PLND: pelvic lymphadenectomy; PALND: para-aortic lymphadenectomy; BT: brachytherapy. The symbols (*, **, ***; #, ##, ###) inserted serve to recall the indication given in the box. Line IIA1 has been removed, as the clinical indications are the same as those described for earlier stages in the corresponding guidelines.

ESGO NCCN ASCO AIOM FIGO BGCS SEOM ESMO JSGO
IA1, LVSI- Cone, no LN staging. Cone or SH. Cone or SH (basic); cone or SH or B type RH + pelvic LN if positive margins (maximal). Cone or SH. Only cone. Only cone. Cone or SH. SH, cone-only if negative margins on frozen section. SH.
IA1, LVSI+ Cone +/− SLN. Cone biopsy + SLN/PLDN.
Type B RH (modified radical hysterectomy).
As NCCN (basic); RH type B + PLND +/− paraortic (may offer SLN or RT if patient not fit for surgery) (maximal). RH type B + PLND + salpingo-oophorectomy
**.
SH + PLDN. PLND or SLNB. Cone or SH + PLDN. SH + PLDN. SH or RH + PLDN.
IA2 Cone or SH +/− SLN if LVSI +/−. Type B RH (modified radical hysterectomy) + PLDN (+/− SLN)
*.
SH (basic); (maximal): see ASCO IA1 LVSI+. ** B type RH + PLND. Cone/SH/RH (achieve clear margins). SH + PLND +/− PALDN. RH/SH + PLND +/− PALND, SLN. RH + PLDN.
IB1 If LN + in imaging, only RT. SLN + frozen section: RH to be defined + PLND + salpingo-oophorectomy
***.
* SH (basic); B type RH + PLND (SLN) (maximal). ** C type RH + PLND. RH + PLND + salpingo-oophorectomy. C type RH + PLND +/− PALND
#.
RH + PLND +/− PALND, SLN
##.
RH or RT-CHT.
IB2 *** * NACT + SH (basic); RT-CHT + adjuvant hysterectomy (only if residual disease) (maximal)
###.
C type RH for correlation between tumor size and paracervix rish invasion. C type RH + PLND. RT-CHT + BT. # ## RH or RT-CHT.