Table 1.

Brain MRI WD semiquantitative scale—scoring system (proposed by Dusek et al., 2020) [53].

	Normal/Absent	Mild/Moderate	Severe
Acute toxicity score (evaluated as hyperintensity on T2-weighted and FLAIR sequences)
Putamen	0	1	2
Caudate nucleus	0	1	2
Thalamus	0	1	2
Mesencephalon	0	1	2
Pons	0	1	2
Other areas (sepcify)	0	1	2
Chronic damage score (evaluated as hypointensity on T2/T2*/SWI sequences)
Globus pallidus	0	1
Putamen	0	1
Caudate nucleus	0	1
Thalamus	0	1
Dentate nucleus	0	1
Atrophy (assessed on T1 sequences)
Cortical	0	1	2
Central	0	1	2
Midbrain	0	1	2
Cerebellar	0	1	2