Figure 1.

Flow study diagram. Twelve of eligibility patients refused to participate with justification “not enough time”, “discomfort feeling and exhausted”. Ten of the eligible patients did not meet the inclusion criteria, such as self-reported symptoms and incident respiratory disease, five patients had high blood pressure at rest, three patients failed the balance test, two patients lacked cooperation during spirometry, and two patients had difficulty answering the questionnaires. Seven patients were excluded after the physical fitness test: four patients shown to have decreased systolic blood pressure after a 30 s sit-to-stand test; two patients showed 6MWT, staggering, and leg cramps; and one patient gave up the trials.