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. 2024 Jun 28;12(7):1443. doi: 10.3390/biomedicines12071443

Figure 6.

Figure 6

Respiratory SARS-CoV-2 infection downregulates some enzyme genes involved in fatty acid oxidation. (A) Summary of Gene Set Enrichment Analysis (GSEA) performed using the Hallmark fatty acid metabolism gene set in SARS-CoV-2 or influenza A virus (IAV)-infected hamsters at 3-, 30-, and 60-days post-infection (dpi) compared to mock controls. Dotted lines indicate false discovery rate (FDR) q value = 0.1 for positive (red) and negative (blue) coordinate regulation. n = 3 hamsters/infection group/time point. (B,C) Heatmaps showing changes in the expression of enzyme genes involved in fatty acid synthesis (B) and fatty acid oxidation (C). (D) Schematic overview of expression changes in enzyme genes involved in fatty acid oxidation in the SARS-CoV-2 group. Blue, white, and red indicate log2 (fold change) values of <−2, 0, and >2, respectively. Symbols indicate significant differences compared to mock controls (M) by the Wald test (* FDR q < 0.05, # FDR q < 0.1). n = 3 hamsters/infection group/time point.