Skip to main content
. 2024 Jul 2;12(7):1467. doi: 10.3390/biomedicines12071467

Figure 1.

Figure 1

Xenobiotics activate CYP450 gene expression. (1) Xenobiotics translocate to inside the cell. (2) It binds to the NR. (3) Xenobiotic binding induces conformational changes that facilitate its translocation into the nucleus through binding to nuclear translocator. (4) The ligand-bound NR–partner complex nuclear translocator binds to xenobiotic response elements. (5) Initiates the transcription of CYP genes, including those encoding CYP450 enzymes, in various tissues. Created with https://www.biorender.com/ (accessed on 5 June 2024).