| CYP1 |
Biotransformation |
CYP1A1 |
Granisetron and riociguat |
| CYP1A2 |
Polycyclic aromatic hydrocarbons, caffeine, tizanidine, clozapine, olanzapine, theophylline, alosetron, duloxetine, melatonin, pirfenidone, ramelteon, tasimelteon, acetaminophen, antipyrine, bufuralol, ondansetron, phenacetin, and tacrine |
| CYP2 |
Biotransformation |
CYP2A6 |
Nicotine, coumarin, and valproic acid |
| CYP2B6 |
Efavirenz |
| CYP2C8 |
Metabolizes over 60 clinically relevant drugs, including montelukast, pioglitazone, repaglinide, and rosiglitazone |
| CYP2C9 |
Warfarin, carvedilol, celecoxib, glipizide, glimepiride, ibuprofen, irbesartan, losartan, phenytoin, and tolbutamide |
| CYP2C19 |
Omeprazole, lansoprazole, and phenobarbital |
| CYP2D6 |
Antidepressants, antipsychotics, beta-blockers, antiretroviral agents, antiarrhythmics, morphine derivatives, and Tamoxifen |
|
|
CYP2E1 |
Ethanol, acetaminophen, theophylline, and verapamil metabolism |
| CYP3 |
Biotransformation |
CYP3A4 |
Alprazolam, amlodipine, buspirone, calcium channel blockers, caffeine, citalopram, clopidogrel, cocaine, cyclosporine, diazepam, erythromycin, drugs, montelukast, quetiapine, sertraline, sildenafil, statin drugs, tacrolimus, warfarin, zolpidem, estradiol, lidocaine, losartan, and many chemotherapeutic agents |
| CYP4 |
Fatty acid metabolism |
CYP4A |
Arachidonic acid (AA) |
| CYP5 |
Thromboxane A2 synthesis |
- |
| CYP7 |
Bile acid biosynthesis |
CYP7A1 |
Converts cholesterol to 7α-hydroxycholesterol |
| CYP7B1 |
Metabolizes dehydroepiandrosterone |
| CYP8 |
Bile acid and prostacyclin biosynthesis |
CYP8A1 |
Converts prostaglandin H2 to thromboxane A |
| CYP11 |
Steroid biosynthesis |
CYP11A1 |
Converts cholesterol to pregnenolone plus 4-methylpentanal |
| CYP17 |
Steroid biosynthesis |
CYP17A1 |
Converts corticosterone to cortisol |
| CYP19 |
Steroid biosynthesis |
CYP19A1 |
Metabolizes androstenedione and testosterone |
| CYP20 |
Unknown function |
- |
| CYP21 |
Steroid biosynthesis |
CYP21A2 |
Converts progesterone to deoxycortisone in pregnancy |
| CYP24 |
Vitamin D degeneration |
CYP24A1 |
Converts 1,25-dihydroxyvitamin D3 (calcitriol) to 1α,24R,25-trihydroxyvitamin D3 |
| CYP26 |
Retinoic acid hydroxylation |
CYP26A1, CYP26B1, and CYP26C1 |
Convert retinoic acid to 4-hydroxyretinoic acid |
| CYP27 |
Vitamin D3 and bile acid biosynthesis |
CYP27C1 |
Converts retinol (vitamin A1) to 3,4-didehydroretinol (vitamin A2) |
| CYP39 |
Cholesterol synthesis |
CYP39A1 |
Converts 24-hydroxycholesterol to 7α,24-dihydroxycholesterol |
| CYP46 |
Cholesterol synthesis |
CYP46A1 |
Converts cholesterol to 24(S)-hydroxycholesterol |
| CYP51 |
Cholesterol synthesis |
CYP51A1 |
Lanosterol |
