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Nirmatrelvir, a covalent, reversible SARS-CoV-2 Mpro inhibitor, and examples of its structurally closely related compounds (maximum common substructure (MCS)) with known Mpro inhibitory activity from the PubChem Database. The low potency criterion was IC50 or Ki > 10 μM or Inh% at 20 μM < 75%.
