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. 2024 Jul 4;14(7):797. doi: 10.3390/biom14070797

Figure 15.

Figure 15

Small, irreversible covalent inhibitor of SARS-CoV-2 Mpro GRL-1720 and examples of its structurally closely related compounds (by maximum common substructure (MCS)) with known Mpro inhibitory activity from the PubChem Database. The low potency criterion was IC50 or Ki > 10 μM or Inh% at 20 μM < 75%.