| Study | Treatment | NYHA class* | Outcome |
|---|---|---|---|
| MDC | Metoprolol | II, III | Improved clinical state without effect on survival. Reduction in need for transplantation in patients with dilated cardiomyopathy |
| CIBIS I | Bisoprolol | II, III | Trend (non-significant) towards improved survival |
| ANZ trial | Carvedilol | I, II | Carvedilol superior to placebo for morbidity and mortality |
| Carvedilol (US) | Carvedilol | II, III | Carvedilol superior to placebo for morbidity and mortality |
| CIBIS II | Bisoprolol | III, IV | Bisoprolol superior to placebo for morbidity and mortality |
| MERIT-HF | Metoprolol | II, III | Metoprolol superior to placebo for morbidity and mortality |