Figure 4. Mixed Pattern Diseases Correlate with Psychiatric Disorders.

Path diagram with standardized estimates for the correlated factors model used in genomic structural equation modelling with four factors of immune-mediated disease and five factors of psychiatric disorders. Latent variables are represented as circles. The genetic component of each phenotype is represented with a circle because the genetic component is a latent variable that is not directly measured but is inferred using linkage disequilibrium score regression. Single-headed arrows are factor loadings; double-headed arrows connecting back to the same origin are variances; and double-headed arrows connecting two variables are correlations. All residual variances, factor loadings, non-significant correlations, as well as significant correlations with factors other than the mixed pattern factor are left out for simplicity, but all factors are allowed to correlate in this model. Disease abbreviations are defined in Table 1.