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(Insert) Kinetic schemes of dynein hydrolyzing one or two ATPs per step. The histogram of dwell times between successive on-axis steps of dynein under limiting (8 µM), KM (20 µM), and saturating (1 mM) ATP concentrations. Red curves represent a fit to a single exponential decay (8 µM and 1 mM) or Gamma distribution (20 µM) to determine the stepping rate (k, ± s.e.).
