Table 1:

Candidate genes prioritized using our CST algorithm predicted to have a major role establishing a tumor immune microenvironment favorable for aPD1 response in mice and humans. Candidates in bold are the top twelve for each QTL that comprise the 48-gene panel used as the predictive markers in Figure 4.

Chromosome (mouse ortholog)	Human gene symbol
5	ACOX3, ADD1, AFAP1, C4orf48, EMILIN1, FNDC4, IFT172, MPV17, MXDA, NRBP1, SH3BP2, STK32B, YWHAH
9	ACP5, ANLN, C19orf38, CADM1, CBL, CD3D, CD3E, CD3G, CDON, DYNC2H1, FAT3, FLI1, ICAM1, IFT46, IL10RA, NAALAD2, NCAM1, PKNOX2, PRKCSH, REXO2, S1PR2, SLC37A2, SLC37A2, SLC37A4, ST14, TAGLN, THY, TYK2, UBASH3B, ZNF426
15	APOBEC3H, APOL6, C1QTNF6, C22orf23, CSF2RB, CYTH4, ELFN2, FAM83F, GPAA1, GRAP2, GTPBP1, IL2RB, KDELR3, PDGFB, RAC2, SH3BP1, SYNGR1
17	ABCA3, ABCG1, AIF1, ATP6V1G2, C2, DDAH2, DDR1, FGD2, FKBP5, FPR2, GPSM3, HLA-A, HLA-DMA, HLA-DMB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB5, HLA-E, HLA-F, LMF1, LSM2, LST1, LTB, MMP25, MSLN, MYO1F, NME4, PGLYRP2, PSMB8, PSMB9, RASAL3, RPS18, SIK1, SYNGAP1, TAP1, TAP2, TEAD3, TNF, UBASH3A, UBD