TABLE 2.
Comparison of N2 NA amino acid residues at positions 275 and 431 in avian, swine, and human viruses
| Host | Isolate | Subtype | Residue 275 | Residue 431 | Reference or source of sequencea | Relative activity for the following substrateb:
|
||
|---|---|---|---|---|---|---|---|---|
| NeuAcα2-3Gal | NeuAcα2-6Gal | NeuGcα2-3Gal | ||||||
| Avian | A/turkey/Colorado/8/72 | H5N2 | Ile | Pro | This study | |||
| A/duck/Hong Kong/7/75 | H3N2 | Ile | Pro | This study | ||||
| A/duck/Hong Kong/24/76 | H3N2 | Ile | Pro | D21184 | ++++ | + | + | |
| A/goose/Hong Kong/10/76 | H3N2 | Ile | Pro | This study | ||||
| A/duck/Hong Kong/245/77 | H3N2 | Ile | Pro | D21185 | ||||
| A/mallard/New York/6750/78 | H2N2 | Ile | Pro | This study | ++++ | + | + | |
| A/duck/Hong Kong/342/78 | H5N2 | Ile | Pro | This study | ||||
| A/turkey/Minnesota/833/80 | H4N2 | Ile | Pro | This study | ||||
| A/chicken/Pennsylvania/1370/83 | H5N2 | Ile | Pro | M12051 | ||||
| A/gull/Delaware/475/86 | H2N2 | Ile | Pro | This study | ||||
| A/gull/Delaware/2838/87 | H7N2 | Ile | Pro | This study | ++++ | + | ++ | |
| Swine | A/swine/Italy/1850/77 | H3N2 | Val | Lys | This study | ++++ | ||
| A/swine/Italy/635/87 | H3N2 | Val | Gly | This study | ++++ | |||
| Human | A/Singapore/1/57 | H2N2 | Ile | Pro | This study | ++++ | + | ++ |
| A/Rhode Island/5−/57 | H2N2 | Ile | Pro | J02156 | ||||
| A/Leningrad/134/57 | H2N2 | Ile | Pro | L37329 | ||||
| A/Ann Arbor/6/60 | H2N2 | Val | Pro | This study | ++++ | + | + | |
| A/England/12/62 | H2N2 | Val | Gln | This study | ++++ | ++ | ||
| A/Berlin/3/64 | H2N2 | Val | Gln | This study | ||||
| A/Tokyo/3/67 | H2N2 | Val | Lys | This study | ++++ | ++ | +++ | |
| A/Cordoba/522/67 | H2N2 | Val | Lys | 11 | ||||
| A/England/10/67 | H2N2 | Val | Lys | 11 | ||||
| A/Georgia/1/67 | H2N2 | Val | Lys | 11 | ||||
| A/Poland/6/67 | H2N2 | Val | Lys | 11 | ||||
| A/Korea/426/68 | H2N2 | Val | Gln | This study | ++++ | + | ||
| A/Aichi/2/68 | H3N2 | Val | Lys | M55059 | ++++ | ++ | +++ | |
| A/NT/60/68 | H3N2 | Val | Lys | J02136 | ||||
| A/Hong Kong/8/68 | H3N2 | Val | Lys | U42630 | ++++ | +++ | ||
| A/Perg/1/68 | H2N2 | Val | Lys | 11 | ||||
| A/Udorn/307/72 | H3N2 | Val | Glu | J02168 | ++++ | +++ | ++ | |
| A/Victoria/3/75 | H3N2 | Val | Glu | J02173 | ||||
| A/Bangkok/1/79 | H3N2 | Val | Glu | K01150 | ++++ | ++ | ++ | |
| A/Los Angeles/2/87 | H3N2 | Val | Glu | This study | ++++ | +++ | ++ | |
a
Letter-number designations are GenBank accession numbers.
b
Relative levels of activity for each substrate from lowest (+) to highest (++++) are indicated for the viruses that were tested and for which sequence data are available.