Table 1.

Case history summary.

Group	Cases	Mean Age at Death (years)*	Sex	Mean PMI (hours)*	Neuropathology	APOE genotype
Down syndrome	20	59.8 ± 4.99	7 F / 13 M	17.95 ± 11.71	Equivalent to A3, B3, C3 score or Braak V-VI, Thal 5	ε3/ε3: 13, ε4/ε4: 2, ε3/ε4: 3, ε2/ε4: 1
EOAD	20	63 ± 4.07	5 F / 15 M	27.47 ± 12.76	Equivalent to A3, B3, C3 score or Braak V-VI, Thal 4	ε3/ε3: 10, ε4/ε4: 3, ε3/ε4: 5, ε2/ε3: 2
LOAD	20	# 82.1 ± 6.37	10 F / 10 M	33.22 ± 19.19	A3, B3, C3 or Braak VI	ε3/ε3: 6, ε4/ε4: 3, ε3/ε4: 7, ε2/ε3: 2, ε2/ε4: 2
Control	20	66.4 ± 13.04	9 F / 11 M	59.50 ± 27.30	≤ A1, B1, C1	N/A

^*Mean Age at death and Mean PMI ± Standard deviation.

^#Significant differences by one-way ANOVA.