Table 3.
PGS analyses results.
| Sample | Population | Sex | TotalN | Total N.case(%) | Total N.control(%) | Top5% N | Top5% N.case(%) | Top5% N.control(%) | Estimate | StdError | OR (95%CI) | P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AOU | AA | Both | 47,516 | 6,090 (12.82%) | 41,426 (87.18%) | 2,303 | 292 (12.68%) | 2,011 (87.32%) | −0.01 | 0.07 | 0.99 (0.87–1.13) | 0.92 |
| AOU | AA | Male | 20,989 | 3,699 (17.62%) | 17,290 (82.38%) | 1,009 | 181 (17.94%) | 828 (82.06%) | 0.00 | 0.09 | 1.00 (0.84–1.19) | 0.98 |
| AOU | AA | Female | 26,527 | 2,391 (9.01%) | 24,136 (90.99%) | 1,294 | 111 (8.58%) | 1,183 (91.42%) | −0.08 | 0.11 | 0.93 (0.75–1.14) | 0.48 |
| AOU | EA | Both | 116,027 | 7,672 (6.61%) | 108,355 (93.39%) | 5,710 | 792 (13.87%) | 4,918 (86.13%) | 0.79 | 0.04 | 2.21 (2.03–2.39) | 5.5580 |
| AOU | EA | Male | 45,919 | 4,405 (9.59%) | 41,514 (90.41%) | 2,365 | 451 (19.07%) | 1,914 (80.93%) | 0.73 | 0.06 | 2.07 (1.85–2.32) | 5.3937 |
| AOU | EA | Female | 70,108 | 3,267 (4.66%) | 66,841 (95.34%) | 3,345 | 341 (10.19%) | 3,004 (89.81%) | 0.86 | 0.06 | 2.35 (2.08–2.65) | 1.0443 |
| AOU | LA | Both | 36,368 | 2,461 (6.77%) | 33,907 (93.23%) | 1,818 | 217 (11.94%) | 1,601 (88.06%) | 0.69 | 0.08 | 1.99 (1.71–2.33) | 3.2018 |
| AOU | LA | Male | 12,358 | 1,543 (12.49%) | 10,815 (87.51%) | 646 | 134 (20.74%) | 512 (79.26%) | 0.69 | 0.1 | 1.99 (1.62–2.44) | 3.5411 |
| AOU | LA | Female | 24,010 | 918 (3.82%) | 23,092 (96.18%) | 1,172 | 83 (7.08%) | 1,089 (92.92%) | 0.68 | 0.12 | 1.98 (1.56–2.51) | 2.2008 |
| IB | AA | Both | 1,829 | 912 (49.86%) | 917 (50.14%) | 158 | 77 (48.73%) | 81 (51.27%) | −0.01 | 0.2 | 0.99 (0.66–1.47) | 0.96 |
| IB | AA | Male | 647 | 371 (57.34%) | 276 (42.66%) | 54 | 28 (51.85%) | 26 (48.15%) | −0.02 | 0.36 | 0.98 (0.48–1.98) | 0.95 |
| IB | AA | Female | 1,182 | 541 (45.77%) | 641 (54.23%) | 104 | 49 (47.12%) | 55 (52.88%) | −0.02 | 0.25 | 0.98 (0.60–1.61) | 0.95 |
| IB | EA | Both | 6,375 | 2,801 (43.94%) | 3,574 (56.06%) | 406 | 248 (61.08%) | 158 (38.92%) | 0.63 | 0.11 | 1.88 (1.50–2.35) | 3.3708 |
| IB | EA | Male | 2,862 | 1,301 (45.46%) | 1,561 (54.54%) | 180 | 110 (61.11%) | 70 (38.89%) | 0.54 | 0.17 | 1.71 (1.23–2.39) | 1.5603 |
| IB | EA | Female | 3,513 | 1,500 (42.70%) | 2,013 (57.30%) | 226 | 138 (61.06%) | 88 (38.94%) | 0.71 | 0.15 | 2.03 (1.50–2.76) | 4.4106 |
Note: N.case: number of cases; N.control: number of controls. Significant P-values are in bold. AOU: All of Us. IB: Indiana Biobank. AA: African ancestry. EA: European ancestry. LA: Latino ancestry.