Table 1.
Novel Gene-Sleep Duration Interaction Loci Identified in Cross-Population Meta-Analysis All results herein are from the M1 model. Supplementary Table S21 provides summary statistics according to each population group identified in cross-population results. For the sex column, C denotes combined sex, and F denotes female sex-stratified meta-analysis. For the alleles column, E denotes effect allele, and O denotes other allele used as reference. Bold denotes significance.
| xposure | Variant | Nearest gene(s) | Position (hg38) |
Alleles (E/O) | AF | N | Sex | Population Groups | Trait | BM1_G (seM1_G) | BGxE (seGxE) | PM1_G | PGxE | PG,GxE | Psex_diff |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Loci Identified by 1df Interaction Test | |||||||||||||||
| STST | rs113144211 | WBP1L | 10:102808541 | C/CG | 0.551 | 279527 | F | AFR, EAS, EUR, HIS, SAS | PP | 0.12 (0.04) | 0.40 (0.09) | 1.60E-03 | 7.82E-06 | 3.54E-11 | 8.84E-05 |
| LTST | rs5384795532 | FAM98A | 2:33903659 | C/G | 0.102 | 41814 | F | AFR, EAS, EUR, HIS | SBP | 1.12 (0.40) | −5.09 (0.86) | 5.27E-03 | 3.32E-09 | 2.35E-08 | 3.59E-06 |
| Loci Identified by 2df Joint Test, Driven by Interaction Effect | |||||||||||||||
| STST | rs764584102 | YWHAB | 20:44851866 | G/A | 0.023 | 47678 | C | AFR,HIS | PP | 0.14 (0.34) | −3.65 (0.73) | 6.93E-01 | 6.38E-07 | 3.88E-09 | 6.87E-02 |
| LTST | rs14319996952 | ALG10B | 12:37297511 | T/C | 0.016 | 29473 | F | EUR, HIS | PP | −0.57 (0.44) | −3.28 (0.78) | 1.88E-01 | 2.46E-05 | 4.55E-09 | 4.07E-04 |
1
denotes the variant was identified using the two-step approach.
2
denotes variants novel for BP.