Table 3.
Novel BP Loci Identified by the 2df Joint Test, Not Driven by the Interaction Effect
| Exposure | Variant | Nearest gene(s) | Position (hg38) |
Alleles (E/O) | Sex | AF | N | Population Groups | Trait | BM1_G (seM1_G) | BGxE (seGxE) | PM1_G | PGxE | PG,GxE | Psex_diff2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Loci Identified by 1df Interaction Test | |||||||||||||||
| STST | rs114831731 | AHCYL1 | 1:109970740 | A/T | C | 0.009 | 23897 | HIS | PP | 0.85 (0.64) | −6.27 (1.04) | 1.87E-01 | 1.57E-09 | 7.34E-11 | 5.67E-04 |
| rs144229676 | ZNF521 | 18:25303461 | A/C | C | 0.019 | 27119 | HIS | DBP | 2.32 (0.70) | −7.23 (1.18) | 8.70E-04 | 8.10E-10 | 1.80E-09 | 5.00e-01 | |
| rs1035064 | ZNF682 | 19:19997730 | T/C | M | 0.019 | 392939 | EUR | SBP | −0.27 (0.18) | 2.10 (0.36) | 1.62e-01 | 4.82E-09 | 5.76E-08 | 1.52E-04 | |
| rs1129580071 | PAK5 | 20:9805888 | C/T | C | 0.005 | 23897 | HIS | PP | 2.09 (0.97) | −10.83 (1.78) | 3.03E-02 | 1.28E-09 | 1.23E-08 | ||
| rs7520866771 | KRTAP13-2 | 21:30362234 | C/G | C | 0.002 | 30009 | EUR | DBP | 2.12 (0.87) | −8.71 (1.23) | 1.47E-02 | 1.46E-12 | 5.68E-13 | ||
| LTST | rs372262693 | TG, SLA | 8:133069499 | T/C | C | 0.023 | 23897 | HIS | PP | 0.62 (0.41) | −4.91 (0.82) | 1.34E-01 | 2.33E-09 | 7.11E-09 | 2.43E-01 |
| Loci Identified by 2df Joint Test, Driven by Interaction Effect | |||||||||||||||
| STST | rs1438637721 | MROH7 | 1:54707218 | T/G | C | 0.006 | 23902 | HIS | SBP | −1.56 (1.06) | −6.99 (1.74) | 1.47E-01 | 5.79E-05 | 1.84E-10 | |
| rs1411177151 | KCNJ3 | 2:155446948 | C/T | C | 0.021 | 23897 | HIS | PP | 0.51 (0.44) | −4.29 (0.76) | 2.53E-01 | 1.74E-08 | 2.45E-09 | 7.86E-02 | |
| rs170112821 | ZNF385D | 3:22386254 | C/G | C | 0.006 | 23897 | HIS | PP | −0.01 (0.79) | −6.00 (1.20) | 9.93E-01 | 5.86E-07 | 4.13E-10 | 1.97E-01 | |
| rs7649852491 | EFNA5 | 5:105713137 | T/C | C | 0.002 | 26230 | EUR | PP | 0.97 (1.48) | −11.78 (2.00) | 5.09E-01 | 4.06E-09 | 6.45E-12 | ||
| rs5427451701 | WWOX | 16:78323227 | A/C | C | 0.009 | 23897 | HIS | PP | −0.36 (0.72) | −4.96 (1.19) | 6.20E-01 | 3.14E-05 | 5.00E-09 | 2.05E-03 | |
| LTST | rs5337240621 | BRINP3 | 1:190792851 | TA/T | C | 0.011 | 34442 | AFR | PP | 1.13 (0.60) | −4.40 (1.18) | 6.03E-02 | 1.92E-04 | 3.69E-09 | 3.56E-04 |
| rs1382886951 | CRBN | 3:3295965 | G/A | C | 0.006 | 23897 | HIS | DBP | 0.57 (0.68) | −5.50 (1.08) | 4.07E-01 | 3.46E-07 | 1.31E-09 | ||
| rs1429661821 | ALCAM | 3:104791665 | T/C | C | 0.006 | 26230 | EUR | DBP | −0.20 (0.62) | −5.37 (1.01) | 7.50E-01 | 1.01E-07 | 1.21E-09 | ||
| rs5400415831 | PAM | 5:103002447 | A/G | C | 0.003 | 26230 | EUR | PP | −1.54 (1.20) | −6.50 (1.66) | 1.99E-01 | 8.93E-05 | 6.93E-10 | ||
| rs1139521421 | SDK1 | 7:3917121 | A/C | C | 0.005 | 23902 | HIS | SBP | −0.28 (1.20) | −9.07 (1.90) | 8.18E-01 | 1.81E-06 | 5.49E-10 | ||
| rs1113924011 | JMJD1C | 10:65029197 | T/G | C | 0.007 | 23897 | HIS | DBP | 0.49 (0.63) | −5.71 (1.00) | 4.32E-01 | 1.27E-08 | 2.28E-10 | ||
| rs7728629321 | ATP8A2 | 13:25395875 | T/C | C | 0.002 | 30009 | EUR | DBP | −0.11 (0.70) | −4.85 (1.00) | 8.70E-01 | 1.31E-06 | 1.28E-09 | ||
All results herein are from the M1 model. Supplementary Tables S21-S22 provides summary statistics according to each population group-specific cohort for rs59680540 and rs150586434, and according to each population group for rs34761985 and rs13032423 below. For the sex column, C denotes combined sex meta-analysis. For the alleles column, E denotes effect allele, and O denotes other allele used as reference. Bold denotes significance.
1
denotes variants novel for BP.
2
Empty cell in Psex_diff indicates the variant, after quality control, was not found in both sex-stratified meta-analyses.