Table 3.

Proinflammatory cytokines at 3 months of treatment with biological agents and Wilcoxon signed rank test results between 3 months and start of therapy (statistical significance was considered for p < 0.05).

	TNF-α at 3 Months (pg/mL)	IL-23 at 3 Months (pg/mL)	IL-17A at 3 Months (pg/mL)	IL-17F at 3 Months (pg/mL)
Mean	26.04	88.54	41.52	48.53
Quartile 25	18.2	60.6	35.7	43
Median	19.4	67.2	39	47
Quartile 75	23.8	71	48.7	53
Min	17.2	20.6	33	37
Max	78	466.8	66.3	65
Standard deviation	15.66	88.18	8.38	6.81
Standard Error	3.264583129	18.38710243	1.747484383	1.420844384
95% Confidence	[19.6450049, 32.4419351].	[52.5028037, 124.5789163].	[24.5500323, 58.4847477].	[45.7499763, 51.3195837].
Average of differences	−4.38	−22.23	−2.11	−2.587
Z	−1.83	−4.53	−0.81	−1.65
r	−0.38	−0.94	−0.17	−0.36
p	0.068	<0.000	0.417	0.098