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Radical production pathway involved in ferroptosis centered on the TCA cycle. This diagram shows the process in which carbon derived from glucose and carbon backbones of amino acids are metabolized during the TCA cycle, and how the electrons generated during this process are involved in ferroptosis. Only a few key enzymes that play important roles in metabolism are shown. PPP, pentose phosphate pathway; P-L•, phospholipid radical; PDH, pyruvate dehydrogenase.
