Table 2.

Genome-wide significant results for CAC in the COPDGene study with replication in the DHS study for participants of European ancestry. For the GWA analyses, all p-values less than 5 × 10⁻⁸ are in green, and yellow highlighted cells are marginally significant with 5 × 10⁻⁸ < p < 0.05. For the interactions and smoking status analyses, the significance level was based on a Bonferroni correction of 0.05/2 = 0.025 for the 2 SNPs. As a result, the p-values less than 0.025 are in green, and yellow highlighted cells are marginally significant with 0.025 < p < 0.05. Base pairs are based on build GR38.

SNP/CHR/Base Pair/Gene/Coded Allele	Study	All			Male			Female			SNP by Sex Interaction			Former Smokers			Current Smokers			SNP by Smoking Status Interaction
		$\mathit{\beta }$	SE	p	$\mathit{\beta }$	SE	p	$\mathit{\beta }$	SE	p	$\mathit{\beta }$	SE	p	$\mathit{\beta }$	SE	p	$\mathit{\beta }$	SE	p	$\mathit{\beta }$	SE	p
rs9349379 6 12903725 PHACTR1 G	COPDGene	0.22	0.04	1.7 × 10−7	0.13	0.06	0.03	0.32	0.06	4.4 × 10−8	0.19	0.08	0.02	0.15	0.05	7.5 × 10−3	0.34	0.07	6.2 × 10−7	0.19	0.09	0.03
	DHS	0.26	0.10	7.4 × 10−3	0.10	0.13	0.43	0.45	0.15	2.5 × 10−3	0.30	0.19	0.11	0.31	0.15	0.03	0.12	0.24	0.61	−0.45	0.28	0.11
rs10757272 9 22088261 CDKN2B-AS1 T	COPDGene	0.31	0.04	7.1 × 10−14	0.36	0.06	1.0 × 10−9	0.26	0.06	6.4 × 10−6	−0.10	0.08	0.21	0.28	0.05	7.7 × 10−8	0.34	0.07	1.7 × 10−7	0.07	0.08	0.40
	DHS	0.22	0.09	0.02	0.29	0.11	0.01	0.17	0.15	0.25	−0.11	0.17	0.51	0.15	0.14	0.28	0.40	0.24	0.09	0.14	0.25	0.58